Investigating the role of HLA-F in immune regulation and disease
Molecular and functional investigation of the role of HLA-F in immune regulation
This study is looking at a protein called HLA-F that helps your immune system fight diseases like cancer and autoimmune conditions, and it's for anyone interested in how this protein works and its role in keeping us healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11091504 on NIH RePORTER |
What this research studies
This research focuses on understanding the HLA-F protein, which plays a critical role in immune responses related to various diseases, including cancers, HIV, and autoimmune conditions like ALS. The study aims to explore the different forms of HLA-F and how they function in the body, particularly in how they present peptides and interact with immune receptors. By using advanced structural studies and specific antibodies, researchers will investigate how these forms of HLA-F are regulated and their implications in tumor surveillance and autoimmunity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cancers, HIV, or autoimmune diseases such as ALS.
Not a fit: Patients with conditions unrelated to immune regulation or those not expressing HLA-F may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into immune regulation, potentially improving treatments for cancers and autoimmune diseases.
How similar studies have performed: While the specific investigation of HLA-F is relatively novel, similar studies on immune regulation have shown promising results in understanding immune responses.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Adams, Erin June — University of Chicago
- Study coordinator: Adams, Erin June
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.