Investigating the role of histones in burn-related blood vessel damage
Extracellular Histones in Burn-induced Microvascular Hyperpermeability
This study is looking at how certain proteins released during injuries, called histones, might harm blood vessels in burn patients, and it aims to find new ways to help prevent complications from these injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11026341 on NIH RePORTER |
What this research studies
This research focuses on understanding how extracellular histones, which are proteins released during tissue injury, contribute to blood vessel damage in burn patients. The study will analyze the levels of these histones in the blood of burn patients and animal models, and examine how they affect the permeability of blood vessels, potentially leading to complications like organ dysfunction. By exploring the molecular mechanisms involved, the research aims to identify new therapeutic targets to mitigate these harmful effects. The approach includes correlating histone levels with clinical outcomes and testing the effects of histone inhibitors on vascular leakage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have suffered burn injuries and are experiencing complications related to blood vessel permeability.
Not a fit: Patients with burn injuries who do not exhibit signs of microvascular hyperpermeability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce complications from burns by targeting histone-related pathways.
How similar studies have performed: While the role of histones in other conditions has been studied, this specific investigation into burn-induced microvascular hyperpermeability is relatively novel.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Wu, Mack H — University of South Florida
- Study coordinator: Wu, Mack H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.