Investigating the role of high-density lipoproteins in preventing kidney injury after surgery
Perioperative high-density lipoproteins and postoperative AKI
This study is looking at how a type of good cholesterol called HDL might help protect your kidneys during and after heart or blood vessel surgery, and it involves checking blood samples from patients like you to see if higher HDL levels can lead to less kidney damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10823345 on NIH RePORTER |
What this research studies
This research focuses on understanding how high-density lipoproteins (HDL) can influence kidney health during and after surgical procedures. The study will involve a group of patients undergoing cardiac or vascular surgery, where researchers will measure levels of specific proteins and microRNAs in the blood to see if they correlate with reduced kidney injury. Additionally, the research will explore the effects of administering HDL to animal models to assess its potential protective benefits against kidney damage. By analyzing blood and urine samples, the study aims to uncover important insights into how HDL can help maintain kidney function during the perioperative period.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for cardiac or vascular surgery who may be at risk for postoperative acute kidney injury.
Not a fit: Patients who are not undergoing cardiac or vascular surgery or those with pre-existing severe kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing kidney injury in patients undergoing surgery, improving their overall recovery and quality of life.
How similar studies have performed: Previous research has indicated a potential link between HDL levels and kidney protection, suggesting that this approach may yield promising results.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Smith, Loren Elisa — Vanderbilt University Medical Center
- Study coordinator: Smith, Loren Elisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.