Investigating the role of Heparanase-1 in eye infections caused by herpes virus
HPSE in Ocular Herpes Infection
This study is looking at how a protein called Heparanase-1 affects the severity of eye infections caused by the herpes virus, with the goal of finding new ways to help people with these infections feel better and protect their vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10914258 on NIH RePORTER |
What this research studies
This research focuses on understanding how Heparanase-1 (HPSE) contributes to the severity of eye infections caused by the herpes simplex virus type-1 (HSV-1). The study examines the mechanisms by which HPSE promotes inflammation and viral replication in the eye, potentially leading to vision loss. By exploring the interactions between HPSE and specific proteins involved in inflammation, the researchers aim to identify new therapeutic targets that could mitigate the effects of the virus. Patients may benefit from new treatments that reduce the severity of their ocular infections and improve their overall eye health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing ocular herpes infections or those at high risk for such infections.
Not a fit: Patients with non-viral causes of eye disease or those not affected by herpes simplex virus type-1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the severity of ocular herpes infections and prevent vision loss.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in viral infections, suggesting potential for success in this approach.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Shukla, Deepak — University of Illinois at Chicago
- Study coordinator: Shukla, Deepak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.