Investigating the role of gut bacteria in treating ALS
Microbiome and intestinal barrier in ALS therapy
This study is looking at how the balance of bacteria in the gut can affect people with ALS, and it aims to find new ways to help by combining diet changes with approved medications to improve health and motor function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11043225 on NIH RePORTER |
What this research studies
This research explores how the balance of gut bacteria affects patients with Amyotrophic Lateral Sclerosis (ALS) and aims to develop new treatment strategies by restoring healthy gut microbiome relationships. The approach involves combining dietary interventions with FDA-approved medications to improve motor neuron function and overall health in ALS patients. By studying the gut microbiome's impact on disease progression, the research seeks to identify potential therapeutic targets that could enhance patient outcomes. The study builds on previous findings that suggest a link between gut health and neurological diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Amyotrophic Lateral Sclerosis who are interested in exploring new treatment options.
Not a fit: Patients with other neurological disorders not related to ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve the quality of life and potentially extend the lifespan of ALS patients.
How similar studies have performed: Previous research has shown promising results in similar approaches targeting the gut microbiome for neurological conditions, indicating potential for success in this area.
Where this research is happening
Chicago, United States
- Jesse Brown VA Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Sun, Jun — Jesse Brown VA Medical Center
- Study coordinator: Sun, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.