Investigating the role of gut bacteria in early onset colorectal cancer
Pathogenesis of Early Onset Colorectal Cancer: Microbiome Contributions and Mechanisms
This study is looking at how the bacteria in our gut might be linked to early onset colorectal cancer in people under 50, and it aims to find out if certain types of bacteria could help us understand and prevent this cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11061470 on NIH RePORTER |
What this research studies
This research focuses on understanding how the microbiome, or gut bacteria, may contribute to early onset colorectal cancer (EO-CRC) in individuals under 50. By comparing the microbial profiles and immune responses of EO-CRC patients to those of age-matched controls, the study aims to identify specific bacterial signatures and their potential role in cancer development. The researchers will utilize both retrospective and prospective cohorts to gather data on biofilm formation and its association with cancer progression. This approach may reveal critical insights into the mechanisms behind EO-CRC and pave the way for new prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early onset colorectal cancer, particularly those under 50 years of age.
Not a fit: Patients with late onset colorectal cancer or those without any colorectal cancer diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and prevention strategies for early onset colorectal cancer.
How similar studies have performed: While the specific focus on early onset colorectal cancer and its microbiome is relatively novel, previous studies have shown success in linking gut microbiota to various forms of cancer.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Sears, Cynthia — Johns Hopkins University
- Study coordinator: Sears, Cynthia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.