Investigating the role of gut bacteria in Alzheimer's disease
Official title: Role of IgA-biome in intestinal dysbiosis and brain changes in Alzheimer's disease
Funded at University of North Dakota · NIH-10836544 · Data updated 2026-11-12
This study is looking at how the bacteria in our gut, especially those covered in a special protein called IgA, might affect the development and worsening of Alzheimer's disease, and it hopes to help people understand how taking care of gut health could be important for brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Dakota NIH-funded |
| Lab location | 1 site (Grand Forks, United States) |
| Project start | May 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $176,250 |
| NIH project number | 5R21AG078598-02 |
| Project ID | NIH-10836544 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly those experiencing gastrointestinal issues.
✕Less likely to help
Patients without Alzheimer's disease or significant gastrointestinal symptoms may not benefit from this research.
What this research studies
This research explores how changes in gut bacteria, specifically those coated with immunoglobulin A (IgA), may contribute to the development and progression of Alzheimer's disease (AD). By analyzing the gut microbiota of mice with a model of AD, the study aims to identify specific bacterial populations that could be linked to brain changes associated with the disease. The researchers will utilize advanced sequencing techniques to characterize these bacteria and their potential impact on inflammation and cognitive function. Patients may benefit from insights into how gut health influences Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting gut microbiota.
How similar studies have gone: Other research has shown promising results linking gut microbiota to neurological conditions, suggesting this approach may yield valuable insights.
Where this research is happening
-
University of North Dakota
Grand Forks, United States Active
Researchers
- Principal investigator: Nookala, Suba — University of North Dakota
- Study coordinator: Nookala, Suba
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.