Investigating the role of gut bacteria and genetics in Crohn's disease complications.
Official title: Role of microbiota, host genetics and mesenteric adipose in Crohn's disease fibrosis and post-op recurrence.
Funded at Cedars-Sinai Medical Center · NIH-10769731 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut, your genes, and fat around your intestines can affect scarring in Crohn's disease, and it aims to create a way to spot patients who might be at higher risk for complications or flare-ups after surgery, with the hope of finding better treatments to help manage this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | January 20, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $367,200 |
| NIH project number | 5R01DK123446-05 |
| Project ID | NIH-10769731 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Crohn's disease, particularly those who are newly diagnosed or have a history of surgery for fibrotic strictures.
✕Less likely to help
Patients with Crohn's disease who do not exhibit signs of fibrosis or have not undergone surgery may not benefit from this research.
What this research studies
This research focuses on understanding how gut microbiota, host genetics, and mesenteric adipose tissue contribute to fibrosis in Crohn's disease. It aims to develop a screening process that combines genetic risk scores and microbiome profiles to identify patients at high risk for developing fibrotic complications or experiencing recurrence after surgery. By analyzing these factors, the study seeks to uncover potential therapeutic targets and improve patient outcomes. The ultimate goal is to pave the way for new treatments that could prevent or manage fibrosis in Crohn's disease patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and managing fibrosis in Crohn's disease, reducing the need for repeated surgeries.
How similar studies have gone: Previous research has shown promise in understanding the role of microbiota in Crohn's disease, but this approach is novel in its focus on integrating genetic and microbiome data for predicting fibrosis.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Devkota, Suzanne — Cedars-Sinai Medical Center
- Study coordinator: Devkota, Suzanne
Related research
Other NIH-funded projects on the same topics.
-
Why Crohn's sometimes returns after surgery: genes, immunity, and gut bugs
This project looks at how a person's genes, immune responses, and gut microbes are linked to Crohn's disease coming back after bowel surgery for people who had ileocolic resection.
-
Exploring how genetics, immune response, and gut microbes affect Crohn's disease recurrence after surgery
This study is looking at how your genes, immune system, and gut bacteria work together to understand why Crohn's disease can come back after surgery, and by participating, you'll help researchers find better ways to prevent and treat the disease.
-
Investigating intestinal fibrosis and inflammation in Crohn's Disease using advanced imaging techniques
This study is looking at a new way to help doctors better understand Crohn's Disease by using a special tool to see signs of inflammation and scarring in the intestines, which can help tell if a patient needs medication or surgery, ultimately aiming to improve treatment and health for those living with the condition.
-
How mechanical stress affects tissue changes in Crohn's disease
This study is looking at how physical stress on the intestines might lead to complications in people with Crohn's disease, especially the narrowing of the intestines, and it hopes to find new ways to treat this issue beyond just using anti-inflammatory medications.
-
Gut microbiome and Parkinson's disease: how gut bugs relate to symptoms and progression
A multi-year study will look at gut bacteria and related markers in people with Parkinson’s disease to understand how the gut-brain connection may influence symptoms and progression.
-
Gut-Brain Axis in Parkinson’s Disease: biomarkers and procedures to track progression
A patient-focused program to study how gut health and the brain interact in Parkinson’s disease using biomarkers and clinical procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.