Investigating the role of gut bacteria and genetics in Crohn's disease complications.
Role of microbiota, host genetics and mesenteric adipose in Crohn's disease fibrosis and post-op recurrence.
This study is looking at how the bacteria in your gut, your genes, and fat around your intestines can affect scarring in Crohn's disease, and it aims to create a way to spot patients who might be at higher risk for complications or flare-ups after surgery, with the hope of finding better treatments to help manage this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10769731 on NIH RePORTER |
What this research studies
This research focuses on understanding how gut microbiota, host genetics, and mesenteric adipose tissue contribute to fibrosis in Crohn's disease. It aims to develop a screening process that combines genetic risk scores and microbiome profiles to identify patients at high risk for developing fibrotic complications or experiencing recurrence after surgery. By analyzing these factors, the study seeks to uncover potential therapeutic targets and improve patient outcomes. The ultimate goal is to pave the way for new treatments that could prevent or manage fibrosis in Crohn's disease patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Crohn's disease, particularly those who are newly diagnosed or have a history of surgery for fibrotic strictures.
Not a fit: Patients with Crohn's disease who do not exhibit signs of fibrosis or have not undergone surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and managing fibrosis in Crohn's disease, reducing the need for repeated surgeries.
How similar studies have performed: Previous research has shown promise in understanding the role of microbiota in Crohn's disease, but this approach is novel in its focus on integrating genetic and microbiome data for predicting fibrosis.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Devkota, Suzanne — Cedars-Sinai Medical Center
- Study coordinator: Devkota, Suzanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.