Investigating the role of glycosaminoglycans in blood cell development
Official title: Core C: GAGomics and Proteomics
Funded at Versiti Wisconsin, INC. · NIH-11001974 · Data updated 2026-11-12
This study is looking at special sugars in bone marrow that help with blood cell development, and it aims to learn how these sugars work with proteins, which could lead to better treatments for blood disorders.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $229,480 |
| NIH project number | 5P01HL151333-05 |
| Project ID | NIH-11001974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or those interested in the biological mechanisms of blood cell development.
✕Less likely to help
Patients with conditions unrelated to blood cell development or those not affected by glycosaminoglycan-related processes may not benefit from this research.
What this research studies
This research focuses on understanding glycosaminoglycans (GAGs), which are complex sugars that play a crucial role in modifying proteins involved in blood cell development. By using advanced mass spectrometry techniques, the research aims to analyze the structural characteristics of GAGs derived from bone marrow. This analysis will help uncover how these molecules interact with proteins and regulate cellular functions, which is essential for understanding blood cell formation and function. Patients may benefit from insights gained about blood disorders and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood-related conditions by enhancing our understanding of blood cell development.
How similar studies have gone: Previous research has shown promising results in understanding glycosaminoglycans and their role in various biological processes, indicating that this approach has potential for success.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Hawkridge, Adam M — Versiti Wisconsin, INC.
- Study coordinator: Hawkridge, Adam M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.