Investigating the role of GIPC3 in hearing and deafness
GIPC3, multifunctional myosin adaptor in mammalian auditory hair cells
This study is looking at a protein called GIPC3 that is important for hearing, to see how changes in this protein can cause hearing loss, using mice to learn more about how it works in the ear and how it interacts with other proteins that help us hear.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10846793 on NIH RePORTER |
What this research studies
This research focuses on understanding how GIPC3, a protein essential for hearing, functions in the auditory system and how mutations in this protein lead to hearing loss. The study utilizes mouse models to explore the molecular mechanisms of GIPC3's role in auditory hair cells, particularly its interactions with other proteins that are critical for hearing. By examining these interactions and the effects of specific mutations, the research aims to uncover the pathways that contribute to inherited deafness.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with inherited forms of deafness, particularly those with mutations in the GIPC3 gene.
Not a fit: Patients with hearing loss not related to genetic mutations in GIPC3 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of hearing loss and potential therapeutic targets for treatment.
How similar studies have performed: Other research has shown success in understanding the genetic basis of hearing loss, making this approach promising but still focused on a specific protein's role.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Frolenkov, Gregory I — University of Kentucky
- Study coordinator: Frolenkov, Gregory I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.