Investigating the role of ghrelin in memory loss related to Alzheimer's disease
GOAT-mediated ghrelin deregulation and hippocampal pathology in Alzheimer's Disease
This study is looking at how a hormone called ghrelin, which comes from the stomach, might help with memory loss in people with Alzheimer's by affecting brain signals, and it hopes to find new ways to improve thinking skills for those dealing with the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project ID | NIH-11050501 on NIH RePORTER |
What this research studies
This research focuses on understanding how ghrelin, a hormone produced in the stomach, affects memory loss in Alzheimer's disease by influencing brain signaling in the hippocampus. The study examines the relationship between ghrelin levels and cognitive deficits associated with Alzheimer's, particularly looking at how ghrelin interacts with amyloid beta, a protein linked to the disease. By exploring these mechanisms, the research aims to uncover potential therapeutic targets for improving cognitive function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those experiencing significant memory decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance memory and cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has indicated that targeting the ghrelin system may have potential benefits in cognitive function, although this specific approach is still being explored.
Where this research is happening
Lawrence, United States
- University of Kansas Lawrence — Lawrence, United States (Active)
Researchers
- Principal investigator: Du, Heng — University of Kansas Lawrence
- Study coordinator: Du, Heng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.