Investigating the role of genetics and the microbiome in diabetes for cystic fibrosis patients
Genetics, glycemic control and the microbiome in cystic fibrosis
This study is looking at how genes and gut bacteria affect blood sugar control in people with cystic fibrosis-related diabetes, and it will test a special bionic pancreas device to help manage blood sugar levels while also checking how it impacts lung health and overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10884900 on NIH RePORTER |
What this research studies
This research focuses on cystic fibrosis related diabetes (CFRD), a common complication in cystic fibrosis patients that can lead to severe health issues. The study aims to understand how genetic factors and the microbiome influence glycemic control in individuals with CFRD. Participants will be involved in a clinical trial testing a bionic pancreas device designed to improve blood glucose management. The research will evaluate not only glycemic control but also its effects on lung function and overall health in cystic fibrosis patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with cystic fibrosis who are experiencing poorly controlled diabetes.
Not a fit: Patients without cystic fibrosis or those with well-controlled diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diabetes management and better health outcomes for cystic fibrosis patients.
How similar studies have performed: Previous research has shown promise in using artificial pancreas technology for diabetes management, indicating potential success for this approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Brenner, Laura N — Massachusetts General Hospital
- Study coordinator: Brenner, Laura N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.