Investigating the role of genetic mutations in heart disease among older kidney disease patients
Clonal Hematopoiesis of Indeterminate Potential in Chronic Kidney Disease Patients
This study is looking at how a common genetic change that happens as we age, called CHIP, might impact heart health in older people who have chronic kidney disease, and it aims to find out if this change affects the progression of kidney issues and the risk of heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11113942 on NIH RePORTER |
What this research studies
This research focuses on understanding how clonal hematopoiesis of indeterminate potential (CHIP), a condition characterized by age-related genetic mutations, affects cardiovascular health in older patients with chronic kidney disease (CKD). By analyzing data from the Chronic Renal Insufficiency Cohort (CRIC), the study aims to explore the relationship between CHIP and the progression of CKD as well as the risk of atherosclerotic cardiovascular disease (ASCVD). The research will utilize advanced genetic sequencing techniques and long-term clinical data to identify potential mechanisms linking CHIP to these health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who have been diagnosed with chronic kidney disease.
Not a fit: Patients under the age of 65 or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cardiovascular risks in older patients with chronic kidney disease.
How similar studies have performed: Previous research has successfully linked CHIP to cardiovascular disease, indicating that this study builds on established findings in a novel patient population.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Kelly, Tanika Nicole — University of Illinois at Chicago
- Study coordinator: Kelly, Tanika Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.