Investigating the role of GATA3 in facial development abnormalities
The role of GATA3 in hemifacial microsomia
This study is looking at how a specific gene called GATA3 affects the way facial features develop in people with hemifacial microsomia, a condition that causes one side of the face to be smaller or different, using mice to learn more about how this gene helps shape the face.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11045779 on NIH RePORTER |
What this research studies
This research focuses on understanding how the GATA3 gene influences the development of facial structures in individuals with hemifacial microsomia (HFM), a congenital condition characterized by facial asymmetry. The study uses mouse models to explore the gene's role in the migration of neural crest cells, which are crucial for proper facial formation. By analyzing gene expression changes in these cells, the research aims to identify the underlying mechanisms that lead to the facial defects associated with HFM.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hemifacial microsomia or those with related craniofacial birth defects.
Not a fit: Patients without craniofacial abnormalities or those with conditions unrelated to GATA3 or neural crest cell development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential therapeutic strategies for treating hemifacial microsomia and related craniofacial abnormalities.
How similar studies have performed: Previous research has shown promising results in understanding gene roles in craniofacial development, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Clouthier, David E. — University of Colorado Denver
- Study coordinator: Clouthier, David E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.