Investigating the role of G-quadruplex DNA in aging and Alzheimer's disease
G-quadruplex DNA in senescence of the neurovascular unit
This study is looking at how aging impacts the brain's blood flow and nutrient delivery system, especially in people with Alzheimer's, to find new ways to keep our brains healthy as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10875749 on NIH RePORTER |
What this research studies
This research focuses on the neurovascular unit (NVU), which is crucial for brain health as it regulates blood flow and nutrient delivery. The study aims to understand how aging affects the NVU and its components, such as neurons and astrocytes, particularly in the context of Alzheimer's disease. Researchers will explore the role of G-quadruplex DNA structures in this process, using animal models to assess changes in brain aging and cognitive function. By examining these mechanisms, the research seeks to identify potential therapeutic targets for improving brain health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive decline or those at risk for Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's disease who are not experiencing significant cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline associated with aging and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of G-quadruplex DNA in cellular aging, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Tsvetkov, Andrey — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Tsvetkov, Andrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.