Investigating the role of fungi in Crohn's disease
The Intestinal Mycobiome and IBD
This study is looking at how fungal infections, especially from Candida, might make Crohn's disease worse, and it's for people with Crohn's who may have a genetic link to the condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11042833 on NIH RePORTER |
What this research studies
This research focuses on understanding how fungal infections, particularly those caused by Candida species, may contribute to the worsening of Crohn's disease (CD). Researchers will explore the relationship between the gut microbiome and CD, especially in patients who have a genetic predisposition to the condition. By using a mouse model that mimics CD, the study aims to uncover the molecular mechanisms through which Candida infections can exacerbate intestinal inflammation. This could lead to new insights into the management of CD and its associated complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's disease, particularly those with a family history of the condition.
Not a fit: Patients without Crohn's disease or those who do not have a genetic predisposition to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with Crohn's disease by targeting fungal infections.
How similar studies have performed: Previous studies have shown a correlation between fungal infections and inflammatory bowel diseases, suggesting that this research could build on established findings.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Di Martino, Luca — Case Western Reserve University
- Study coordinator: Di Martino, Luca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.