Investigating the role of FOG2 isoforms in heart blood vessel disease
Official title: FOG2 isoforms in Coronary Microvascular Disease
Funded at University of Pennsylvania · NIH-11094937 · Data updated 2026-11-12
This study is looking at how a protein called FOG2 affects the tiny blood vessels in the heart, which can help us find new ways to treat Coronary Microvascular Disease, a condition that can lead to heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $582,671 |
| NIH project number | 5R01HL175485-02 |
| Project ID | NIH-11094937 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Ischemic Heart Disease or related cardiovascular conditions.
✕Less likely to help
Patients with non-cardiovascular diseases or those without any form of heart disease may not benefit from this research.
What this research studies
This research focuses on Coronary Microvascular Disease (CMVD), which affects the small blood vessels in the heart and is a significant contributor to Ischemic Heart Disease. The study aims to understand how different forms of the FOG2 protein influence the growth and maintenance of these blood vessels. By examining the interactions between FOG2 and another protein called HIF1a, researchers hope to uncover mechanisms that could lead to new treatments. The research involves both laboratory experiments and studies in living organisms to assess how FOG2 affects vascular cells.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies for patients suffering from Coronary Microvascular Disease.
How similar studies have gone: While the specific approach of targeting FOG2 isoforms is novel, similar research has shown promise in understanding angiogenesis in cardiovascular diseases.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Guerraty, Marie a — University of Pennsylvania
- Study coordinator: Guerraty, Marie a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.