Investigating the role of FKBP5 in heart rhythm disorders
Official title: FKBP5 AND CARDIAC ARRHYTHMOGENESIS
Funded at Baylor College of Medicine · NIH-11235428 · Data updated 2026-11-12
This study is looking at how a protein called FKBP5 influences heart rhythm in people with atrial fibrillation, and it hopes to find new ways to help manage this condition by understanding what happens when this protein is missing in heart cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 20, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $98,915 |
| NIH project number | 3R01HL164838-02S1 |
| Project ID | NIH-11235428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with atrial fibrillation or those at high risk for developing this condition.
✕Less likely to help
Patients without any history of heart rhythm disorders or those who do not have atrial fibrillation may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called FKBP5 affects heart rhythm, particularly in patients with atrial fibrillation (AF), the most common type of arrhythmia. Researchers will explore how the absence of FKBP5 in heart cells may lead to increased risk of AF by examining its effects on heart cell activity and tissue remodeling. The study aims to identify the mechanisms by which FKBP5 deficiency contributes to arrhythmias and to evaluate potential new treatments that target this pathway. Patients may benefit from insights that could lead to innovative therapies for managing AF.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that significantly reduce the risk of atrial fibrillation in patients.
How similar studies have gone: Previous studies have shown promising results in understanding the role of FKBP5 in other biological contexts, but this specific approach to atrial fibrillation is relatively novel.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li, Na — Baylor College of Medicine
- Study coordinator: Li, Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.