Investigating the role of FKBP5 in heart rhythm disorders
Official title: FKBP5 AND CARDIAC ARRHYTHMOGENESIS
Funded at Baylor College of Medicine · NIH-11002341 · Data updated 2026-11-12
This study is looking at how a protein called FKBP5 affects the heart and could help us understand why some people develop atrial fibrillation, a common heart rhythm problem, so we can find new ways to keep hearts healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 20, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $495,545 |
| NIH project number | 5R01HL164838-02 |
| Project ID | NIH-11002341 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of atrial fibrillation or those at high risk for developing this condition.
✕Less likely to help
Patients without any history of heart rhythm disorders or those with other unrelated cardiac conditions may not benefit from this research.
What this research studies
This research focuses on understanding how FKBP5, a protein found in heart tissues, influences the development of atrial fibrillation (AF), a common heart rhythm disorder. Researchers will explore the mechanisms by which a deficiency of FKBP5 may lead to increased risk of AF, particularly through its effects on heart cell activity and tissue remodeling. By studying both heart muscle cells and fibroblasts, the project aims to identify new therapeutic strategies that could help reduce the risk of AF in patients. The findings could lead to innovative treatments targeting the FKBP5 pathway to improve heart health.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of atrial fibrillation in patients.
How similar studies have gone: Previous studies have shown promising results in understanding the role of various proteins in cardiac arrhythmias, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li, Na — Baylor College of Medicine
- Study coordinator: Li, Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.