Investigating the role of fibroblast cells in prostate enlargement
Fibroblast subsets in BPH pathogenesis
This study is looking at how certain types of cells in the prostate might be causing the enlargement and urinary problems that many older men experience with benign prostatic hyperplasia (BPH), and it hopes to find new ways to treat this common issue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10899754 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific fibroblast cell subsets contribute to benign prostatic hyperplasia (BPH), a condition that causes prostate enlargement and urinary issues in older men. By analyzing clinical samples and employing advanced genomic techniques, the study aims to identify the interactions between these fibroblast subsets and prostate epithelial cells that lead to BPH symptoms. The goal is to uncover the underlying mechanisms of BPH pathogenesis, which could inform the development of more effective, targeted therapies for this common condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are older men experiencing symptoms of benign prostatic hyperplasia, such as urinary urgency and frequency.
Not a fit: Patients with prostate conditions unrelated to benign prostatic hyperplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for benign prostatic hyperplasia, improving quality of life for affected patients.
How similar studies have performed: Previous research has shown promise in understanding the role of fibroblasts in various tissue pathologies, suggesting that this approach could yield valuable insights into BPH.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Pollack, Jonathan R — Stanford University
- Study coordinator: Pollack, Jonathan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.