Investigating the role of fibrinogen in pancreatic cancer progression
Official title: Novel Pathogenic Roles and Mechanisms of Fibrinogen in Pancreatic Cancer
Funded at Michael E Debakey VA Medical Center · NIH-11067740 · Data updated 2026-11-12
This study is looking at how a protein called fibrinogen might make pancreatic cancer worse in U.S. Veterans, with the goal of finding new ways to help treat this tough disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michael E Debakey VA Medical Center NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX005806-02 |
| Project ID | NIH-11067740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma, especially those who are U.S. Veterans.
✕Less likely to help
Patients with other types of cancer or those without pancreatic ductal adenocarcinoma may not benefit from this research.
What this research studies
This research focuses on understanding how fibrinogen, a protein involved in blood clotting, contributes to the aggressive nature of pancreatic ductal adenocarcinoma (PDAC), particularly in U.S. Veterans who are more affected by this cancer. The study aims to explore the mechanisms by which increased fibrinogen levels may promote cancer progression through specific signaling pathways, leading to worse outcomes for patients. By examining the relationship between fibrinogen and cancer characteristics such as metastasis and resistance to chemotherapy, the researchers hope to identify new therapeutic strategies that could improve patient care.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that improve survival rates and quality of life for patients with pancreatic cancer.
How similar studies have gone: While the role of fibrinogen in cancer is recognized, this specific approach targeting its mechanisms in pancreatic cancer is relatively novel and has not been extensively tested.
Where this research is happening
-
Michael E Debakey VA Medical Center
Houston, United States Active
Researchers
- Principal investigator: Yao, Qizhi C. — Michael E Debakey VA Medical Center
- Study coordinator: Yao, Qizhi C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.