Investigating the role of fibrin in pneumonia
Official title: Fibrin in the Infected Lung
Funded at Boston University Medical Campus · NIH-11031354 · Data updated 2026-11-12
This study is looking at how a protein called fibrin, which helps with blood clotting, influences the severity of pneumonia, and it aims to find better treatments by understanding how fibrin affects the immune response in patients and mice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $681,858 |
| NIH project number | 5R01HL171499-02 |
| Project ID | NIH-11031354 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with pneumonia, particularly those experiencing severe symptoms or complications.
✕Less likely to help
Patients with pneumonia who do not exhibit significant fibrin presence in their lungs may not benefit from this research.
What this research studies
This research focuses on understanding how fibrin, a protein involved in blood clotting, affects pneumonia outcomes. By examining patients and mouse models, the study aims to identify different types of pneumonia based on the presence of fibrin in the lungs. Researchers will explore how fibrin interacts with immune cells like neutrophils, potentially leading to more severe lung damage. The goal is to develop targeted therapies that can improve treatment for specific pneumonia subtypes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pneumonia, reducing complications and improving recovery for patients.
How similar studies have gone: Previous research has shown that targeting specific inflammatory pathways can improve outcomes in pneumonia, suggesting that this approach may also yield beneficial results.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Mizgerd, Joseph P — Boston University Medical Campus
- Study coordinator: Mizgerd, Joseph P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.