Investigating the role of FGF23 peptides in chronic kidney disease
Official title: Role of FGF23 peptides in chronic kidney disease (CKD)
Funded at Northwestern University at Chicago · NIH-10978217 · Data updated 2026-11-12
This study is looking at how a hormone called FGF23, which comes from your bones, affects people with chronic kidney disease (CKD) and aims to find better ways to treat related health problems like heart issues and anemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $607,714 |
| NIH project number | 5R01DK132657-03 |
| Project ID | NIH-10978217 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease, particularly those experiencing complications like anemia or cardiovascular issues.
✕Less likely to help
Patients with acute kidney injury or those not diagnosed with chronic kidney disease may not benefit from this research.
What this research studies
This research focuses on understanding how FGF23 peptides, which are hormones secreted by bone, affect patients with chronic kidney disease (CKD). It explores the relationship between these peptides and various health issues such as cardiovascular mortality, anemia, and iron metabolism disturbances. By examining the secretion and physiological functions of different forms of FGF23, the study aims to identify new therapeutic approaches to mitigate the adverse outcomes associated with CKD. Patients may benefit from insights that could lead to improved treatments targeting FGF23-related complications.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve health outcomes for patients with chronic kidney disease.
How similar studies have gone: While the role of FGF23 in CKD is being explored, this specific investigation into the distinct functions of FGF23 peptides is relatively novel and has not been extensively tested in prior research.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: David, Nicolae Valentin — Northwestern University at Chicago
- Study coordinator: David, Nicolae Valentin
Related research
Other NIH-funded projects on the same topics.
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How FGF23 hormone fragments affect kidney disease, anemia, and heart health
This project explores whether different fragments of the hormone FGF23 made by bone and blood change iron levels, anemia, and heart risk in people with chronic kidney disease.
-
Racial and ethnic disparities in kidney disease progression and onset
Aimed at understanding why Black adults with or at risk for chronic kidney disease experience different outcomes and onset ages compared with other groups.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
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Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.