Investigating the role of FAT cadherins in blood vessel changes
Official title: FAT cadherins and vascular remodeling
Funded at Albert Einstein College of Medicine · NIH-10983758 · Data updated 2026-11-12
This study is looking at how certain proteins called FAT cadherins affect the way blood vessels change and grow, which is important for understanding and treating conditions like atherosclerosis, and it involves testing these ideas in animals to find better ways to help people with vascular diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $527,407 |
| NIH project number | 5R01HL163635-03 |
| Project ID | NIH-10983758 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or suffering from atherosclerosis or other vascular diseases.
✕Less likely to help
Patients with non-vascular related conditions or those not at risk for atherosclerosis may not benefit from this research.
What this research studies
This research focuses on understanding how FAT cadherins influence the remodeling of blood vessels, which is crucial in diseases like atherosclerosis and other vascular conditions. By studying the behavior of vascular smooth muscle cells (SMCs) and the effects of FAT cadherins on their growth and function, the research aims to uncover new mechanisms that could lead to better treatments for vascular diseases. The approach includes using animal models to observe the effects of manipulating FAT cadherin activity on vascular health and disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating serious vascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of cadherins in vascular biology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Sibinga, Nicholas E — Albert Einstein College of Medicine
- Study coordinator: Sibinga, Nicholas E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.