Investigating the role of Fascin in brain development and function
Official title: Fascin in brain development and function
Funded at Emory University · NIH-10828882 · Data updated 2026-11-12
This study is looking at a protein called Fascin to see how it helps the brain grow and work properly, especially in guiding nerve connections during development and keeping them strong in adults, which could help us understand brain disorders better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $188,935 |
| NIH project number | 5R21NS132393-02 |
| Project ID | NIH-10828882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who may have conditions related to brain development or function.
✕Less likely to help
Patients with acute brain injuries or those who do not have any neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding how Fascin, a protein that bundles actin filaments, influences the development and functioning of the brain. It examines how Fascin is involved in guiding the growth of axons during brain development and how it may contribute to the formation and maintenance of synaptic connections in the adult brain. The study employs advanced imaging techniques, molecular manipulation, and various assays using cell cultures and brain tissues to explore these processes. By understanding these mechanisms, the research aims to shed light on the underlying biology of brain disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain development and potential therapeutic targets for brain disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of actin dynamics in neuronal development, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Zheng, James Q — Emory University
- Study coordinator: Zheng, James Q
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.