Investigating the role of extracellular histones in burn injuries and their effects on blood vessel permeability
Extracellular Histones in Burn-induced Microvascular Hyperpermeability
This study is looking at how certain proteins released during burn injuries might cause problems with blood flow and organ function, and it aims to find ways to help prevent these issues in burn patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11084675 on NIH RePORTER |
What this research studies
This research focuses on understanding how extracellular histones, which are proteins released during tissue injury, contribute to complications following burn injuries. The study will analyze the levels of these histones in burn patients and animal models, and how they affect blood vessel permeability, leading to organ dysfunction. By exploring the mechanisms behind histone-induced endothelial barrier breakdown, the research aims to identify potential therapeutic targets to mitigate these effects. The approach includes correlating histone levels with organ dysfunction and testing the effects of histone inhibitors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have suffered burn injuries and are experiencing complications related to microvascular permeability.
Not a fit: Patients with burn injuries who do not exhibit complications related to microvascular leakage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce complications from burn injuries by targeting the harmful effects of extracellular histones.
How similar studies have performed: While the role of extracellular histones in other conditions has been explored, this specific investigation into burn-induced microvascular hyperpermeability is relatively novel.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Wu, Mack H — University of South Florida
- Study coordinator: Wu, Mack H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.