Investigating the role of exosomes and RNA in heart failure
Functional role and therapeutic targeting of exosomes and extracellular RNA biomarkers in heart failure
This study is looking at tiny particles called exosomes and their RNA to see if they can help us better understand heart failure and find new ways to treat it, which could lead to better tests and treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11123161 on NIH RePORTER |
What this research studies
This research focuses on understanding how exosomes and their RNA content can serve as biomarkers for heart failure (HF) and how they may be targeted for new therapies. By analyzing plasma RNA signatures associated with different HF phenotypes, the research aims to identify novel biomarkers that can help in risk stratification and treatment strategies. The study also explores how these exosomal RNAs influence cellular communication and signaling pathways related to heart failure progression. Patients may benefit from improved diagnostic tools and potential new treatments derived from this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure or those at high risk for developing heart failure.
Not a fit: Patients with heart conditions unrelated to heart failure may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for heart failure patients.
How similar studies have performed: Previous research has shown promise in using exosomes and RNA as biomarkers in various conditions, indicating potential success in this novel approach for heart failure.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Das, Saumya — Massachusetts General Hospital
- Study coordinator: Das, Saumya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.