Investigating the role of ERBB4 in melanoma without BRAF mutations
Is ERBB4 a Driver of BRAF WT Melanomas?
['FUNDING_R15'] · AUBURN UNIVERSITY AT AUBURN · NIH-10796093
This study is looking at how changes in the ERBB4 gene might help certain skin cancers grow, especially those that don’t have BRAF mutations, and the goal is to find new ways to treat patients with these types of melanomas.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUBURN UNIVERSITY AT AUBURN (nih funded) |
| Locations | 1 site (Auburn, UNITED STATES) |
| Trial ID | NIH-10796093 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how mutations in the ERBB4 gene may contribute to the growth of cutaneous melanomas that do not have mutations in the BRAF gene. The team will explore how these mutations affect cell signaling pathways that could lead to increased tumor growth. By identifying specific ERBB4 mutations and their impact on melanoma cell lines, the researchers aim to develop new therapeutic strategies that could improve treatment options for patients with this type of cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic cutaneous melanoma that does not have BRAF mutations.
Not a fit: Patients with BRAF mutant melanomas or those with other types of skin cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new treatment options for patients with metastatic BRAF wild-type melanomas, potentially improving their outcomes.
How similar studies have performed: While research on BRAF mutant melanomas has shown significant success, the exploration of ERBB4 in BRAF wild-type melanomas is relatively novel and untested.
Where this research is happening
Auburn, UNITED STATES
- AUBURN UNIVERSITY AT AUBURN — Auburn, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIESE, DAVID J. — AUBURN UNIVERSITY AT AUBURN
- Study coordinator: RIESE, DAVID J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.