Investigating the role of Erbb3 in colorectal cancer development.
Role of Erbb3 kinase activity in colorectal tumorigenesis.
This study is looking at how a protein called Erbb3 affects the growth of colorectal cancer and whether certain changes in this protein can help doctors know if a treatment called anti-PD1 will work better for patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11030255 on NIH RePORTER |
What this research studies
This research aims to understand how Erbb3 kinase activity contributes to the development of colorectal cancer and whether tumors with specific Erbb3 mutations respond better to anti-PD1 antibody treatments. The study involves examining the mechanisms by which Erbb3 influences tumor growth and testing the effectiveness of anti-PD1 therapy in colorectal cancer models with Erbb3 mutations. By using advanced mouse models and cell lines, researchers will explore the potential of targeting Erbb3 to improve treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer, particularly those with mutations in the Erbb3 gene.
Not a fit: Patients without colorectal cancer or those whose tumors do not have Erbb3 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for colorectal cancer patients with specific Erbb3 mutations.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Wang, Zhenghe — Case Western Reserve University
- Study coordinator: Wang, Zhenghe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.