Investigating the role of enteric glial cells in alleviating symptoms of endometriosis
The Enteric Glia as a Possible Target for Symptom Relief in Endometriosis
This study is looking at how certain cells in the gut might affect pain and inflammation in women with endometriosis, and it will also explore how activities like exercise could help improve their symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ponce School of Medicine NIH-funded |
| Lab location | 1 site (Ponce, United States) |
| Project ID | NIH-11045649 on NIH RePORTER |
What this research studies
This research focuses on understanding how enteric glial cells (EGCs) contribute to the symptoms experienced by women with endometriosis, a chronic and painful condition. The study will explore the relationship between EGCs and immune cells, particularly how they may influence inflammation and pain. By examining the effects of non-pharmacological interventions, such as exercise, on EGC activity, the researchers aim to identify new therapeutic targets for symptom relief. The ultimate goal is to provide insights that could lead to improved treatment options for patients suffering from endometriosis-related symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of childbearing age who are diagnosed with endometriosis and experience chronic pelvic pain or gastrointestinal symptoms.
Not a fit: Patients who do not have endometriosis or those with other unrelated chronic pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments that alleviate the chronic pain and gastrointestinal symptoms associated with endometriosis.
How similar studies have performed: While the specific role of enteric glial cells in endometriosis is not well-established, similar research has shown promise in understanding the relationship between glial cells and inflammation in other conditions.
Where this research is happening
Ponce, United States
- Ponce School of Medicine — Ponce, United States (Active)
Researchers
- Principal investigator: Appleyard, Caroline B — Ponce School of Medicine
- Study coordinator: Appleyard, Caroline B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.