Investigating the role of enhancer RNA in brain injury after a stroke
Functional characterization of an enhancer RNA in cerebral ischemia
This study is looking at how certain tiny molecules in our cells, called enhancer RNAs, help the brain heal after a stroke, and it aims to find new ways to support recovery for people who have experienced brain injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10928748 on NIH RePORTER |
What this research studies
This research focuses on understanding how enhancer RNAs (eRNAs) contribute to brain function and recovery following a stroke. By using advanced techniques like RNA sequencing and chromatin mapping, the study aims to identify how these noncoding RNA molecules influence gene expression and brain damage in the adult mouse cortex. The research will explore the molecular interactions and mechanisms of eRNAs, particularly their effects on post-stroke recovery and any differences based on sex. This could provide insights into new therapeutic targets for improving recovery after brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced a stroke or are at risk of stroke-related brain injuries.
Not a fit: Patients who have not experienced a stroke or have chronic, non-acute brain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing recovery and reducing damage in stroke patients.
How similar studies have performed: While the role of eRNAs is a relatively new area of investigation, preliminary studies suggest promising avenues for understanding their impact on stroke recovery.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Dharap, Ashutosh — University of South Florida
- Study coordinator: Dharap, Ashutosh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.