Investigating the role of double-stranded RNA in early gastric cancer development
Official title: The double-stranded RNA (dsRNA) response in gastric pre-neoplasia
Funded at Washington University · NIH-11022662 · Data updated 2026-11-12
This study is looking at how certain signals in the stomach might play a role in the early stages of gastric cancer, especially a condition called pyloric metaplasia, and it aims to find new ways to prevent this type of cancer by using specially modified mice to understand the process better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $547,413 |
| NIH project number | 1R01DK141682-01 |
| Project ID | NIH-11022662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic gastric inflammation or those at high risk for developing gastric cancer.
✕Less likely to help
Patients with established gastric cancer or those without any history of gastric issues may not benefit from this research.
What this research studies
This research focuses on understanding how double-stranded RNA (dsRNA) signaling contributes to the early stages of gastric cancer, particularly in the development of pyloric metaplasia, a pre-cancerous condition. The researchers will explore the mechanisms by which dsRNA accumulates in gastric tissues and how it may influence inflammation and tumor formation. By studying genetically modified mice, they aim to identify key pathways that could be targeted for therapeutic intervention. This work could provide insights into new strategies for preventing gastric cancer.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for gastric cancer, potentially reducing its incidence and improving patient outcomes.
How similar studies have gone: While the role of dsRNA in other cancers has been explored, this specific investigation into gastric pre-neoplasia is relatively novel and untested.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Saenz, Jose Bernardo — Washington University
- Study coordinator: Saenz, Jose Bernardo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.