Investigating the role of DNA in severe asthma
DNA induction of neutrophilic asthma
This study is looking at a tough type of asthma called neutrophilic asthma to see how a substance in the body called extracellular DNA might be causing inflammation, with the hope of finding new treatments to help people who struggle with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10894273 on NIH RePORTER |
What this research studies
This research focuses on neutrophilic asthma, a severe subtype of asthma that currently lacks effective treatments. The study aims to understand how extracellular DNA, which acts as a danger signal in the body, contributes to the inflammation seen in this type of asthma. By using a mouse model, researchers will explore the mechanisms by which DNA activates specific pathways that lead to neutrophilic inflammation in the airways. The goal is to identify potential therapeutic targets that could lead to more effective treatments for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neutrophilic asthma who are experiencing severe symptoms.
Not a fit: Patients with other types of asthma or those who do not have neutrophilic asthma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies for patients with neutrophilic asthma.
How similar studies have performed: Previous studies have shown promising results in understanding the role of extracellular DNA in asthma exacerbations, suggesting that this approach may yield valuable insights.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Alam, Rafeul — National Jewish Health
- Study coordinator: Alam, Rafeul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.