Investigating the role of different capsular types in group B Streptococcus infections.
Capsular serotype in group B Streptococcus colonization and disease
This study is looking at how different types of group B Streptococcus (GBS) bacteria affect people, especially newborns and adults, to help find better ways to prevent infections and create effective vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11122235 on NIH RePORTER |
What this research studies
This research focuses on understanding how various capsular serotypes of group B Streptococcus (GBS) contribute to colonization and disease, particularly in adults and newborns. The study aims to identify the prevalence of non-vaccine type GBS serotypes and their association with invasive infections. By analyzing human samples and employing advanced genome manipulation techniques, researchers will explore the genetic factors that influence GBS pathogenicity and colonization efficiency. This work is crucial for the development of effective vaccines against GBS.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include adults and newborns who are at risk for group B Streptococcus infections.
Not a fit: Patients who are not at risk for group B Streptococcus infections or those who do not carry the bacteria may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines that better protect against group B Streptococcus infections, reducing morbidity and mortality rates.
How similar studies have performed: Previous research has shown success in vaccine development targeting other bacterial infections, indicating potential for similar advancements with GBS.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Ratner, Adam Jonathan — New York University School of Medicine
- Study coordinator: Ratner, Adam Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.