Investigating the role of diet and gut bacteria in improving outcomes for children with severe lung conditions.
Official title: Microbiome and Nutrition in Severe PARDS
Funded at Baylor College of Medicine · NIH-11072336 · Data updated 2026-11-12
This study is looking at how giving kids with severe lung problems early nutrition through their feeding tubes might help them get better and live longer by improving their gut health and reducing lung inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $385,849 |
| NIH project number | 7R01HD104618-04 |
| Project ID | NIH-11072336 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-21 who are critically ill and diagnosed with severe PARDS.
✕Less likely to help
Patients with mild respiratory conditions or those not requiring enteral nutrition may not benefit from this research.
What this research studies
This research focuses on understanding how early enteral nutrition (EEN) can improve survival rates in children suffering from Severe Pediatric Acute Respiratory Distress Syndrome (PARDS). It explores the relationship between diet, gut microbiome, and lung health, hypothesizing that EEN enhances beneficial gut bacteria that produce butyrate, which may reduce lung inflammation. The study will be conducted alongside a larger clinical trial, allowing for a comprehensive analysis of how these dietary interventions can impact critically ill children. By examining these mechanisms, the research aims to identify new therapeutic strategies to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and recovery for children with severe PARDS through dietary interventions.
How similar studies have gone: Previous studies have shown promising results linking early enteral nutrition to improved outcomes in critically ill children, suggesting that this approach may be effective.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Typpo, Katri Vanamo — Baylor College of Medicine
- Study coordinator: Typpo, Katri Vanamo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.