Investigating the role of diacylglycerol kinase in airway smooth muscle functions
Diacylglycerol kinase in airway smooth muscle functions
This study is looking at how a specific enzyme called diacylglycerol kinase (DGK) influences the muscles in your airways, especially for people with asthma, to find new ways to help manage asthma symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10981181 on NIH RePORTER |
What this research studies
This research focuses on understanding how diacylglycerol kinase (DGK) affects airway smooth muscle (ASM) functions, particularly in the context of asthma. It explores the signaling pathways activated by G protein-coupled receptors and receptor tyrosine kinases, which are crucial for airway hyperresponsiveness and inflammation. By examining the effects of inhibiting DGK, the research aims to uncover its role in ASM contraction and proliferation, potentially leading to new therapeutic strategies for asthma management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with asthma, particularly those experiencing airway hyperresponsiveness and allergic reactions.
Not a fit: Patients with non-allergic asthma or those without significant airway hyperresponsiveness may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for asthma by targeting specific signaling pathways involved in airway hyperresponsiveness and inflammation.
How similar studies have performed: Previous research has shown promising results in targeting similar signaling pathways for asthma treatment, indicating potential for success in this approach.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Deshpande, Deepak a — Thomas Jefferson University
- Study coordinator: Deshpande, Deepak a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.