Investigating the role of CYLD in frontotemporal dementia and its connection to ALS.
Official title: Synaptopathy and Pathogenesis in Frontotemporal Dementia: Role of CYLD
Funded at Upstate Medical University · NIH-10680953 · Data updated 2026-11-12
This study is looking at how frontotemporal dementia (FTD) and ALS are connected, especially focusing on a gene called CYLD, to find out how changes in this gene might affect brain health and lead to new treatments, and we’d love to have patients share their genetic and health information to help us understand this better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,364,013 |
| NIH project number | 1RF1AG082478-01 |
| Project ID | NIH-10680953 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals diagnosed with frontotemporal dementia or amyotrophic lateral sclerosis, particularly those with a family history of these conditions.
✕Less likely to help
Patients with other forms of dementia or neurological disorders unrelated to FTD or ALS may not benefit from this research.
What this research studies
This research focuses on understanding frontotemporal dementia (FTD), a leading cause of dementia in individuals under 60, and its relationship with amyotrophic lateral sclerosis (ALS). The study aims to explore the molecular mechanisms behind synaptopathies associated with FTD, particularly the role of the CYLD gene and its mutations. By examining how autophagy, a cellular process, is disrupted in these conditions, the research seeks to identify potential therapeutic strategies that could improve patient outcomes. Patients may be involved in providing genetic and clinical data to help uncover these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for frontotemporal dementia and ALS, potentially improving the quality of life for affected individuals.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and molecular underpinnings of FTD and ALS, suggesting that this approach could yield valuable insights.
Where this research is happening
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Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Yao, Wei-Dong — Upstate Medical University
- Study coordinator: Yao, Wei-Dong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.