Investigating the role of Cyclin D1 in head and neck cancers
Cyclin D1 as a driver of HNSCC
This study is looking at how a protein called Cyclin D1 affects the growth of head and neck cancers, especially in patients who don't have HPV, to find new ways to treat these types of tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11045195 on NIH RePORTER |
What this research studies
This research focuses on head and neck squamous cell carcinomas (HNSCCs), which are cancers that arise in various parts of the head and neck. It examines how Cyclin D1, a protein that regulates cell growth, is often dysregulated in these cancers, particularly in patients who are negative for human papilloma virus (HPV). The study aims to understand the mechanisms behind Cyclin D1's role in cancer development and how its dysregulation can lead to increased tumor growth. By exploring the relationship between Cyclin D1 and glutamine dependence in tumors, the research seeks to identify potential new therapeutic strategies for treating HNSCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with head and neck squamous cell carcinomas, especially those who are HPV-negative.
Not a fit: Patients with head and neck cancers that are HPV-positive may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with head and neck cancers, particularly those who do not respond well to current therapies.
How similar studies have performed: Previous research has shown promising results in targeting Cyclin D1 and glutamine dependence in other cancer types, suggesting potential for success in this area.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Diehl, John Alan — Case Western Reserve University
- Study coordinator: Diehl, John Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.