Investigating the role of complement in ANCA-associated vasculitis and potential therapies
Complement in Pathogenesis and Experimental Therapy of ANCA Disease
This study is looking at how a part of the immune system called the complement system affects inflammation and damage in the kidneys and lungs of people with ANCA-associated vasculitis, and it aims to find better and safer treatments for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10860997 on NIH RePORTER |
What this research studies
This research focuses on understanding how the complement system contributes to the inflammation and organ damage seen in ANCA-associated vasculitis (AAV), a severe autoimmune disease that primarily affects the kidneys and lungs. By using a specialized mouse model, researchers aim to explore the mechanisms of complement involvement in organ injury and test new therapies that target specific complement proteins. The goal is to develop more effective and less toxic treatment options for patients suffering from AAV, moving beyond current non-specific immunosuppressive therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ANCA-associated vasculitis, particularly those experiencing severe symptoms affecting their kidneys or lungs.
Not a fit: Patients with other forms of vasculitis or autoimmune diseases not related to ANCA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that are more effective and have fewer side effects for patients with ANCA-associated vasculitis.
How similar studies have performed: While the role of complement in AAV is not fully understood, there is emerging evidence suggesting that targeting the complement system may offer new therapeutic avenues, indicating a promising area of exploration.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Song, Wenchao — University of Pennsylvania
- Study coordinator: Song, Wenchao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.