Investigating the role of complement C1q in sepsis-related deaths
Complement C1q and sepsis associated fatalities
This study is looking at how a part of the immune system called complement C1q affects people with sepsis, a serious infection, to see if certain immune cells can help predict who might recover and who might not, with hopes of finding new ways to treat sepsis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10873121 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific component of the immune system, known as complement C1q, affects the outcomes of patients suffering from sepsis, a severe inflammatory response to infection. The study aims to identify a particular type of neutrophil that can predict mortality in sepsis patients and examines how the expression of C1q in these cells differs between survivors and those who do not survive. By using mouse models, the researchers will explore the effects of manipulating C1q levels on survival rates, which could lead to new treatment strategies for sepsis. Patients may be monitored for their immune response and how it correlates with their recovery from sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research include critically ill patients diagnosed with sepsis, particularly those showing signs of immune response variability.
Not a fit: Patients with sepsis who do not exhibit significant immune response variability or those with other underlying conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prognostic tools and treatments for sepsis, potentially reducing mortality rates.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in sepsis, but the specific focus on C1q and its role in mortality is a novel approach.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Kim, Minsoo — University of Rochester
- Study coordinator: Kim, Minsoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.