Investigating the role of clonal hematopoiesis in aging and exceptional longevity
CH in Aging and Exceptional Longevity
This study is looking at how changes in blood stem cells, known as clonal hematopoiesis, might influence aging and the risk of diseases like Alzheimer's, cancer, and heart problems, especially in older adults, including centenarians, to see if these changes can help protect against such conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10973774 on NIH RePORTER |
What this research studies
This research explores how clonal hematopoiesis (CH), a condition characterized by mutations in blood stem cells, affects aging and the risk of age-related diseases. By studying unique cohorts of centenarians, the research aims to uncover the relationship between CH and conditions like Alzheimer's disease, cancer, and cardiovascular disease. The study will utilize extensive genetic and clinical data to analyze how CH evolves during healthy aging and its potential protective effects against these diseases. Participants will be drawn from well-characterized groups at the Albert Einstein College of Medicine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 95 and older, particularly those with exceptional longevity.
Not a fit: Patients who are younger than 95 or do not have clonal hematopoiesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into healthy aging and strategies to reduce the risk of age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between clonal hematopoiesis and aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Shastri, Aditi — Albert Einstein College of Medicine
- Study coordinator: Shastri, Aditi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.