Investigating the role of circular RNAs in Alzheimer's Disease
Official title: Systematic and mechanistic assessment of the roles of circRNAs in Alzheimer's Disease
Funded at Brandeis University · NIH-10825615 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in the brain, called circular RNAs, might play a role in the development of Alzheimer's Disease, and it aims to find new ways to help treat the condition by seeing how changing these molecules affects brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project start | April 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $203,125 |
| NIH project number | 5R21AG082109-02 |
| Project ID | NIH-10825615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or those at risk of developing it due to age or genetic factors.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's Disease may not benefit from this research.
What this research studies
This research focuses on understanding how circular RNAs (circRNAs) are involved in the development and progression of Alzheimer's Disease. By studying the regulation of RNA metabolism in the brain, the researchers aim to uncover the mechanisms by which circRNAs may contribute to neurodegeneration. The approach includes manipulating circRNA levels in model organisms to observe the effects on brain function and aging. This could lead to new insights into potential therapeutic targets for Alzheimer's Disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's Disease.
How similar studies have gone: While the role of circRNAs in neurodegenerative diseases is an emerging field, similar studies have shown promising results in understanding RNA metabolism's impact on brain health.
Where this research is happening
-
Brandeis University
Waltham, United States Active
Researchers
- Principal investigator: Kadener, Sebastian — Brandeis University
- Study coordinator: Kadener, Sebastian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.