Investigating the role of circular RNAs in Alzheimer's Disease
Systematic and mechanistic assessment of the roles of circRNAs in Alzheimer's Disease
This study is looking at how certain tiny molecules in the brain, called circular RNAs, might play a role in the development of Alzheimer's Disease, and it aims to find new ways to help treat the condition by seeing how changing these molecules affects brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project ID | NIH-10825615 on NIH RePORTER |
What this research studies
This research focuses on understanding how circular RNAs (circRNAs) are involved in the development and progression of Alzheimer's Disease. By studying the regulation of RNA metabolism in the brain, the researchers aim to uncover the mechanisms by which circRNAs may contribute to neurodegeneration. The approach includes manipulating circRNA levels in model organisms to observe the effects on brain function and aging. This could lead to new insights into potential therapeutic targets for Alzheimer's Disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or those at risk of developing it due to age or genetic factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's Disease.
How similar studies have performed: While the role of circRNAs in neurodegenerative diseases is an emerging field, similar studies have shown promising results in understanding RNA metabolism's impact on brain health.
Where this research is happening
Waltham, United States
- Brandeis University — Waltham, United States (Active)
Researchers
- Principal investigator: Kadener, Sebastian — Brandeis University
- Study coordinator: Kadener, Sebastian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.