Investigating the role of Chromogranin A in aging and health.
Official title: Chromogranin A is an aging risk factor
Funded at Veterans Medical Research Fdn/san Diego · NIH-10839393 · Data updated 2026-11-12
This study is looking at a protein called Chromogranin A (CgA) to see how it changes as we age and how it might affect health issues like high blood pressure and diabetes, with the hope that understanding it better could help improve health for older adults.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Medical Research Fdn/san Diego NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | May 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $182,954 |
| NIH project number | 5R21AG078635-02 |
| Project ID | NIH-10839393 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health conditions such as hypertension or diabetes.
✕Less likely to help
Patients who are younger or do not have age-related health issues may not receive direct benefits from this research.
What this research studies
This research explores how Chromogranin A (CgA), a protein involved in hormone storage, affects aging and related health conditions. The study examines the biological functions of CgA and its peptides, which have opposing effects on inflammation and hypertension. By analyzing genetically modified mice, researchers aim to understand how CgA levels change with age and their potential impact on conditions like hypertension and diabetes. Patients may benefit from insights into how managing CgA could improve health outcomes in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing age-related health issues, potentially improving the quality of life for older adults.
How similar studies have gone: While the role of CgA in aging has not been extensively studied, related research on its peptides has shown promising results in managing inflammation and hypertension.
Where this research is happening
-
Veterans Medical Research Fdn/san Diego
San Diego, United States Active
Researchers
- Principal investigator: Mahata, Sushil K — Veterans Medical Research Fdn/san Diego
- Study coordinator: Mahata, Sushil K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.