Investigating the role of CHI3L1 in neuroinflammation and Alzheimer's disease
Official title: The Neuronal Effect of CHI3L1 in Neuroinflammation & Alzheimer's Disease
Funded at Brown University · NIH-10864955 · Data updated 2026-11-12
This study is looking at how a protein called CHI3L1 affects brain inflammation and the progression of Alzheimer's disease, using special mice that mimic the condition, to help find new ways to understand and treat Alzheimer's.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AG079612-02 |
| Project ID | NIH-10864955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease or those diagnosed with early-stage Alzheimer's.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores how CHI3L1, an inflammatory protein, affects neuroinflammation and the progression of Alzheimer's disease (AD). By studying transgenic mice that model AD, the research aims to understand the mechanisms by which CHI3L1 influences brain inflammation and pathology. The team will analyze the levels of CHI3L1 in the cerebrospinal fluid and its relationship with amyloid plaques and neurofibrillary tangles, which are key features of AD. This work could provide insights into new biomarkers and therapeutic targets for AD.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for Alzheimer's disease.
How similar studies have gone: Previous research has shown that targeting inflammatory pathways can be beneficial in neurodegenerative diseases, suggesting potential success for this approach.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Connolly, Kevin C — Brown University
- Study coordinator: Connolly, Kevin C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.