Investigating the role of CHD8 in neurodevelopmental disorders and cerebellar function
Official title: Chd8-dependent molecular and functional vulnerabilities in developed cerebellar limbic circuits
Funded at University of California at Davis · NIH-10983334 · Data updated 2026-11-12
This study is looking at how changes in the CHD8 gene might affect brain development and contribute to conditions like autism, using mice to learn more about how this gene works in a part of the brain called the cerebellum, with the hope of finding better ways to help those who are affected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | November 10, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $171,063 |
| NIH project number | 5R21MH132834-02 |
| Project ID | NIH-10983334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism spectrum disorder or related neurodevelopmental conditions, particularly those with known CHD8 mutations.
✕Less likely to help
Patients without neurodevelopmental disorders or those whose conditions are unrelated to CHD8 mutations may not benefit from this research.
What this research studies
This research focuses on understanding how mutations in the CHD8 gene contribute to neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and other related conditions. By using mouse models, the study aims to explore the specific roles of CHD8 in the cerebellum, a brain region linked to various NDDs. The researchers will investigate the molecular and functional vulnerabilities associated with CHD8 mutations, which could lead to targeted interventions for affected individuals. The approach combines genetic analysis with behavioral assessments to provide insights into the neurobiological mechanisms underlying these disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals with neurodevelopmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of genetic factors in neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Fioravante, Diasynou — University of California at Davis
- Study coordinator: Fioravante, Diasynou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.