Investigating the role of CDK6 in Alzheimer's Disease
Official title: The role of CDK6 in Alzheimer's Disease
Funded at Tufts Medical Center · NIH-10740243 · Data updated 2026-11-12
This study is looking at how a protein called CDK6 affects aging and its link to Alzheimer's Disease, using special mice to find ways to boost CDK6 that might help prevent or treat the disease, which could lead to new options for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $489,500 |
| NIH project number | 1R21AG078484-01A1 |
| Project ID | NIH-10740243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's Disease or those showing early signs of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's Disease or those with other forms of dementia unrelated to aging may not benefit from this research.
What this research studies
This research explores how the CDK6 protein influences the aging process and its connection to Alzheimer's Disease (AD). By using specialized mouse models, researchers are examining the effects of CDK6 on brain health and the development of AD. The study aims to identify potential therapeutic interventions that could enhance CDK6 activity, which may help in preventing or treating AD. Patients may benefit from insights gained through this research that could lead to new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that slow down or prevent the progression of Alzheimer's Disease.
How similar studies have gone: While the approach of targeting CDK6 in relation to Alzheimer's Disease is relatively novel, similar studies have shown promise in understanding aging mechanisms and their impact on neurodegenerative diseases.
Where this research is happening
-
Tufts Medical Center
Boston, United States Active
Researchers
- Principal investigator: Hu, Miaofen G — Tufts Medical Center
- Study coordinator: Hu, Miaofen G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.