Investigating the role of CDK1 in stomach cancer development
Molecular Functions of CDK1 in Gastric Tumorigenesis
This study is looking at how a protein called CDK1 helps stomach cancer cells grow and survive, especially when they face challenges like infections or chemotherapy, with the hope of finding new ways to treat this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11007221 on NIH RePORTER |
What this research studies
This research focuses on understanding how CDK1, a protein involved in cell cycle regulation, contributes to the development and survival of gastric cancer cells. By examining the molecular mechanisms that lead to the overexpression of CDK1 in response to genotoxic stimuli, such as infections and chemotherapy, the study aims to uncover new insights into gastric cancer biology. The researchers will utilize comprehensive analysis techniques to explore the signaling pathways and transcription factors involved, potentially leading to novel therapeutic targets for gastric cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gastric cancer, particularly those who have not responded well to existing therapies.
Not a fit: Patients with early-stage gastric cancer or those without a confirmed diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve outcomes for patients with gastric cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar molecular pathways in other cancer types, suggesting potential for success in this area as well.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: El-Rifai, Wael — University of Miami School of Medicine
- Study coordinator: El-Rifai, Wael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.