Investigating the role of CD73 in maintaining esophageal tissue health
Official title: The role of CD73 in esophageal epithelial homeostasis
Funded at Children's Hosp of Philadelphia · NIH-10998275 · Data updated 2026-11-12
This study is looking at how a special type of cell called CD73 helps the esophagus heal in people with eosinophilic esophagitis (EoE), especially for those who haven't found relief with current treatments, to discover new ways to support healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 16, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $757,364 |
| NIH project number | 1R01DK138634-01A1 |
| Project ID | NIH-10998275 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis, particularly those who have not achieved remission with existing therapies.
✕Less likely to help
Patients without eosinophilic esophagitis or those who have not been diagnosed with any esophageal conditions may not benefit from this research.
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic allergic condition affecting the esophagus. It aims to understand how CD73, a specific cell type in the esophageal epithelium, contributes to the maintenance and healing of this tissue. The study will explore the mechanisms behind tissue remodeling and barrier function in patients with EoE, particularly those who do not respond to current treatments. By examining the role of CD73+ progenitor cells, the research seeks to identify new therapeutic strategies for promoting healing in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with eosinophilic esophagitis, enhancing their quality of life and reducing healthcare costs.
How similar studies have gone: Previous research has shown promising results in understanding the role of epithelial cells in esophageal conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Muir, Amanda Brooke — Children's Hosp of Philadelphia
- Study coordinator: Muir, Amanda Brooke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.