Investigating the role of CD14 in salt-sensitive hypertension
CD14 and Salt-Sensitive Hypertension
This study is looking at how a protein called CD14 in immune cells affects high blood pressure that gets worse with salt, which many people experience, especially women, to find new ways to help manage this condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-10878711 on NIH RePORTER |
What this research studies
This research focuses on understanding how CD14, a protein found in immune cells, influences salt-sensitive hypertension, a condition affecting 30-50% of people with high blood pressure. The study examines the mechanisms by which CD14 signaling in kidney macrophages can reduce inflammation and oxidative stress, potentially leading to better management of hypertension. By using animal models, specifically Dahl Salt-Sensitive rats, the researchers aim to uncover how the absence of CD14 affects blood pressure and kidney health, particularly in females. The findings could provide insights into new treatment strategies for individuals suffering from salt-sensitive hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with salt-sensitive hypertension, particularly those who may experience renal complications.
Not a fit: Patients with salt-resistant hypertension or those without hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for managing salt-sensitive hypertension, improving health outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune signaling in hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Mattson, David L. — Augusta University
- Study coordinator: Mattson, David L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.