Investigating the role of CCN3 protein in blood vessel health
Matricellular protein CCN3 in vascular homeostasis
This study is looking at how a protein called CCN3 impacts the health of blood vessels, especially for people with conditions like thoracic aortic aneurysm and dissection, to find out if it could help prevent serious blood vessel problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10847479 on NIH RePORTER |
What this research studies
This research focuses on understanding how the CCN3 protein affects the health of blood vessels, particularly in relation to conditions like thoracic aortic aneurysm and dissection. The study examines the role of endothelial cells, which line blood vessels, and how their dysfunction can lead to serious vascular diseases. By using animal models, the researchers aim to uncover the mechanisms by which CCN3 regulates vascular health and its potential as a therapeutic target for preventing vascular complications.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for thoracic aortic aneurysm and dissection, particularly those with genetic predispositions such as Marfan syndrome.
Not a fit: Patients with vascular conditions unrelated to endothelial dysfunction or those without a genetic predisposition to thoracic aortic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate serious vascular diseases, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar proteins in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Lin, Zhiyong — Emory University
- Study coordinator: Lin, Zhiyong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.